The NLRP3 inflammasome, which belongs to the pyrin domain containing 3 family of NOD-
like receptors, has a significant impact on both the innate and adaptive immune responses …

Due to the aging of the global population, the burden of bone-related diseases has
increased sharply. Macrophage, as indispensable components of both innate immune …

Glycolysis has been demonstrated as a crucial metabolic process in bacteria infected
diseases via modulating the activity of pyroptosis. Macrophages are the most abundant …

Pterostilbene (PTE), a natural stilbene found in blueberries and several varieties of grapes,
has several pharmacological activities, including anti-inflammatory and antioxidative …

Objectives Innate immunity plays a significant role in the pathogenesis of
temporomandibular joint osteoarthritis (TMJOA), which is characterized by synovial …

Osteoporosis represents a systemic imbalance in bone metabolism, augmenting the
susceptibility to fractures among patients and emerging as a notable mortality determinant in …

The pathogenesis of osteoarthritis (OA) involves a multifaceted interplay of inflammatory
processes. The initiation of pyroptosis involves the secretion of pro-inflammatory cytokines …

Osteoarthritis (OA) is a chronic disease that causes pain and functional impairment by
affecting joint tissue. Its global impact is noteworthy, causing significant economic losses …

Objective Gadd45β have a regulatory role in cellular inflammation, proliferation and
migration. However, the role of Gadd45β in synovial inflammation in osteoarthritis (OA) …