The bicyclic molecule indole has been in the limelight because of its numerous
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …

Molecular pharming or the technology of application of plants and plant cell culture to
manufacture high-value recombinant proteins has progressed a long way over the last three …

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked
heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer …

Hepatitis C virus (HCV) infection has become a global health problem with enormous risks.
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …

To evaluate the extent of heterogeneity in global estimates of chronic hepatitis B (HBV) and
C (HCV) cited in the published literature, we undertook a systematic review of the published …

We have previously reported that the 6-aminoquinolone chemotype is a privileged scaffold
to obtain antibacterial and antiviral agents. Herein we describe the design, synthesis, and …

Context: Plants transformed by virus-based vectors have emerged as promising tools to
rapidly express large amounts and inexpensive antigens in transient condition. Objective …

With an estimated 3% of the world's population chronically infected, hepatitis C virus (HCV)
represents a major health problem for which an efficient vaccination strategy would be …

Hepatitis C virus (HCV) is one of the leading causes of chronic liver inflammatory disease
(hepatitis), which often leads to more severe diseases, such as liver fibrosis, cirrhosis, and …

Abstract Hepatitis C virus (HCV) NS5B RNA-depended-RNA-polymerase (RdRp) is an
essential enzyme in HCV viral replication and has no functional equivalent in mammalian …