Indole–a promising pharmacophore in recent antiviral drug discovery
A Dorababu - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
The bicyclic molecule indole has been in the limelight because of its numerous
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …
pharmacological potencies. It is used as an excellent scaffold in drug discovery of medicinal …
Combating human viral diseases: will plant-based vaccines be the answer?
S Venkataraman, K Hefferon, A Makhzoum… - Vaccines, 2021 - mdpi.com
Molecular pharming or the technology of application of plants and plant cell culture to
manufacture high-value recombinant proteins has progressed a long way over the last three …
manufacture high-value recombinant proteins has progressed a long way over the last three …
Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis
The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked
heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer …
heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer …
Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective
Z Zhou, J Zhang, E Zhou, C Ren, J Wang… - European Journal of …, 2022 - Elsevier
Hepatitis C virus (HCV) infection has become a global health problem with enormous risks.
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …
Nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase (RdRp) is a component …
Wide variation in estimates of global prevalence and burden of chronic hepatitis B and C infection cited in published literature
SK Basnayake, PJ Easterbrook - Journal of viral hepatitis, 2016 - Wiley Online Library
To evaluate the extent of heterogeneity in global estimates of chronic hepatitis B (HBV) and
C (HCV) cited in the published literature, we undertook a systematic review of the published …
C (HCV) cited in the published literature, we undertook a systematic review of the published …
The versatile nature of the 6-aminoquinolone scaffold: identification of submicromolar hepatitis C virus NS5B inhibitors
We have previously reported that the 6-aminoquinolone chemotype is a privileged scaffold
to obtain antibacterial and antiviral agents. Herein we describe the design, synthesis, and …
to obtain antibacterial and antiviral agents. Herein we describe the design, synthesis, and …
Co-expression of hepatitis C virus polytope–HBsAg and p19-silencing suppressor protein in tobacco leaves
S Mohammadzadeh, F Roohvand… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Plants transformed by virus-based vectors have emerged as promising tools to
rapidly express large amounts and inexpensive antigens in transient condition. Objective …
rapidly express large amounts and inexpensive antigens in transient condition. Objective …
[HTML][HTML] Why is it so difficult to develop a hepatitis C virus preventive vaccine?
C Zingaretti, R De Francesco, S Abrignani - Clinical Microbiology and …, 2014 - Elsevier
With an estimated 3% of the world's population chronically infected, hepatitis C virus (HCV)
represents a major health problem for which an efficient vaccination strategy would be …
represents a major health problem for which an efficient vaccination strategy would be …
New mechanism of hepatic fibrogenesis: hepatitis C virus infection induces transforming growth factor β1 production through glucose-regulated protein 94
MH Jee, KY Hong, JH Park, JS Lee, HS Kim… - Journal of …, 2016 - Am Soc Microbiol
Hepatitis C virus (HCV) is one of the leading causes of chronic liver inflammatory disease
(hepatitis), which often leads to more severe diseases, such as liver fibrosis, cirrhosis, and …
(hepatitis), which often leads to more severe diseases, such as liver fibrosis, cirrhosis, and …
Discovery of HCV NS5B thumb site I inhibitors: core-refining from benzimidazole to indole scaffold
F Zhao, N Liu, P Zhan, X Jiang, X Liu - European journal of medicinal …, 2015 - Elsevier
Abstract Hepatitis C virus (HCV) NS5B RNA-depended-RNA-polymerase (RdRp) is an
essential enzyme in HCV viral replication and has no functional equivalent in mammalian …
essential enzyme in HCV viral replication and has no functional equivalent in mammalian …