Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological
wound healing response and can occur in various organs such as the heart, lung, liver …

Animal experimentation is necessary to characterize human diseases and design adequate
therapeutic interventions. In renal transplantation research, the limited number of in vitro …

Hypothermic machine perfusion (HMP) of kidneys is a long‐established alternative to static
cold storage and has been suggested to be a better preservation method. Today, as our …

Hypothermic machine perfusion (HMP) has become the new gold standard in clinical donor
kidney preservation and a promising novel strategy in higher risk donor livers in several …

Background Deceased after cardiac death donors (DCDs) represent a valuable source of
organs; however, preventing poor outcome is difficult, even with the use of machine …

Normothermic machine perfusion (NMP) of donor kidneys provides the opportunity for
improved graft preservation and objective pre-transplant ex-vivo organ assessment …

Static preservation is currently the most widely used organ preservation strategy; however,
decreased donor organ quality is impacting outcome negatively. M101 is an O 2 carrier with …

Protection of endothelial cell function may explain the benefits of nonoxygenated
hypothermic machine perfusion (MP) for marginal kidney preservation. However, this …

Background. The French uncontrolled donors after circulatory death (DCD) protocol restricts
donor age to< 55 years, no-flow time to< 30 minutes, and functional warm ischemia time to< …

The use of high-risk renal grafts for transplantation requires optimization of pretransplant
preservation and assessment strategies to improve clinical outcomes as well as to decrease …