Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
An overview of quinazolines: Pharmacological significance and recent developments
V Alagarsamy, K Chitra, G Saravanan… - European journal of …, 2018 - Elsevier
Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …
structures and presence of hetero atoms or groupings divulges privileged specificities in …
Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019)
The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …
An appraisal of anticancer activity with structure–activity relationship of quinazoline and quinazolinone analogues through EGFR and VEGFR inhibition: A review
Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …
incidences are reported annually. Heterocyclic compounds have been proved to be very …
Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents
SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study
G Moussa, R Alaaeddine, LM Alaeddine… - European journal of …, 2018 - Elsevier
Click chemistry was used to synthesize a new series of thioquinazolinone molecules
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …
Modified pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives as EGFRWT and EGFRT790M inhibitors: Design, synthesis, and anti-cancer evaluation
ES Nossier, RA Alasfoury, M Hagras… - Journal of Molecular …, 2022 - Elsevier
This study reports design and synthesis of thirteen pyrido [2, 3-d] pyrimidin-4 (3H)-one
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …
A review on fused pyrimidine systems as EGFR inhibitors and their structure–activity relationship
TT Yadav, G Moin Shaikh, MS Kumar… - Frontiers in …, 2022 - frontiersin.org
Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …
New quinazolinone‐based derivatives as DHFR/EGFR‐TK inhibitors: synthesis, molecular modeling simulations, and anticancer activity
Abstract New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their
in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth …
in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth …