Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or groupings divulges privileged specificities in …

Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …

The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Click chemistry was used to synthesize a new series of thioquinazolinone molecules
equipped with propargyl moiety, 1, 2, 3-triazolyl and isoxazolyl rings. Our design was based …

This study reports design and synthesis of thirteen pyrido [2, 3-d] pyrimidin-4 (3H)-one
derivatives as EGFR inhibitors. The antiproliferation activities were tested for all compounds …

Epidermal growth factor receptor (EGFR) belongs to the family of tyrosine kinase that is
activated when a specific ligand binds to it. The EGFR plays a vital role in the cellular …

Abstract New 2‐mercapto‐quinazolin‐4‐one analogs were synthesized and tested for their
in vitro anticancer activity, dihydrofolate reductase (DHFR) inhibition, and epidermal growth …