Interleukin-6 (IL-6) is a pleiotropic cytokine involved in immune regulation. It can activate
janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signaling …

Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

Microbial infections are controlled by host inflammatory responses that are initiated by
innate immune receptors after recognition of conserved microbial products. As inflammation …

Fourteen years have passed since nuclear factor-κB (NF-κB) was first shown to serve as a
molecular lynchpin that links persistent infections and chronic inflammation to increased …

Background Identifying new drug targets for inflammatory bowel disease (IBD) is urgently
needed. The proteome is a major source of therapeutic targets. We conducted a proteome …

The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world.
Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and …

The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Acute lung injury (ALI) has gained increased attention in the field of critical illness research
and is associated with a fatality rate of approximately 50%. Nuclear factor erythroid 2‐related …

IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …