Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune
homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to …

Type I interferon (IFN-I) is induced during innate immune response and is required for
initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and …

STAT3 is an important transcription factor that regulates cell growth and proliferation by
regulating gene transcription of a plethora of genes. This protein also has many roles in …

Ferroptosis is a necrotic form of cell death caused by inactivation of the glutathione system
and uncontrolled iron-mediated lipid peroxidation. Increasing evidence implicates …

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the …

Nature's pharmacy has undoubtedly served humans as an affordable and safer health-care
regime for a long times. Cardamonin, a chalconoid present in several plants has been …

Myeloid immune cells, such as dendritic cells, monocytes, and macrophages, play a central
role in the generation of immune responses and thus are often either disabled or even …

Xanthatin (XT) is a sesquiterpene lactone isolated from the Chinese herb Xanthium, which
belongs to the Asteraceae family. In this study, we developed an inflammation model via …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells that accumulate in tumor-bearing hosts to reduce T cells activity and promote …

Aim Sepsis-induced cardiac dysfunction is the leading cause of higher morbidity and
mortality with poor prognosis in septic patients. Our recent previous investigation provides …