Macrophages are one of the most important cells of the innate immune system and are
known for their ability to engulf and digest foreign substances, including cellular debris and …

Effective cancer therapy requires identification of signaling networks and investigating their
potential role in proliferation and invasion of cancer cells. Among molecular pathways …

Drug resistance in cancer remains a major challenge in oncology, impeding the
effectiveness of various treatment modalities. The nuclear factor-kappa B (NF-κB) signaling …

Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO
pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial …

Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐
regulation and gut dysbiosis are found in T2DM, their roles in DKD are unclear. Here, we …

Background Pneumonia is one of the major causes of death after pathogens infection.
Zingiberis rhizoma (GAN JIANG) is a herb that used in combination with other Chinese …

Spectacular progress has been made in the characterization of human hyper-IgE syndrome
(HIES) over the last 50 years. HIES is a primary immunodeficiency defined as an association …

Systemic sclerosis (SSc) is a complex, immune-mediated rheumatic disease characterised
by excessive extracellular matrix deposition in the skin and internal organs. B cell infiltration …

Purpose: Metastasis remains a major hurdle in treating aggressive malignancies such as
pancreatic ductal adenocarcinoma (PDAC). Improving response to treatment, therefore …

Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin lymphoma associated
with immunodeficiency in the context of human immunodeficiency virus (HIV) infection or …