S-nitrosylation is a selective and reversible post-translational modification of protein thiols by
nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These …

Janus kinase (JAK) inhibitors have been developed as novel immunomodulatory drugs and
primarily used for treating rheumatoid arthritis and other inflammatory diseases. Recent …

African rainforests support exceptionally high biodiversity and host the world's largest
number of active hunter-gatherers [1–3]. The genetic history of African rainforest hunter …

Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have
been discovered in the human population. These eQTLs are active in various tissues and …

Viral seasonality in the aquaculture industry is an important scientific issue for decades.
While the molecular mechanisms underpinning the temperature-dependent pathogenesis of …

Peripheral nerve injury is common, and can lead to skeletal muscle atrophy and dysfunction.
However, the underlying molecular mechanisms are not fully understood. The transcription …

Background Nonsmall-cell lung cancer (NSCLC) is one of the most common malignant
tumors, and the current drugs have not achieved ideal therapeutic effects. The abnormal …

Primary immune regulatory disorders (PIRD) represent a group of disorders characterized
by immune dysregulation, presenting with a wide range of clinical disease, including …

Objective AS is a rheumatic disease characterized by chronic inflammation and bony
ankylosis. This study was to evaluate whether a signal transducer and activator of …

Background Increasing evidence supports a critical role of chronic inflammation in
intracranial aneurysm (IA). Understanding how the immunological alterations in IA provides …