Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide. β-
amyloid plaque (Aβ) deposition and hyperphosphorylated tau, as well as dysregulated …

Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC)
development. The dysregulation of zinc, copper, and selenium homeostasis is associated …

Ferroptosis is an iron-dependent cell death pathway that involves the depletion of
intracellular glutathione (GSH) levels and iron-mediated lipid peroxidation. Ferroptosis is …

Depression is a common mental health disorder, and in recent years, the incidence of
various forms of depression has been on the rise. Most medications for depression are …

Renal ischemia reperfusion (IR) injury is a prevalent inflammatory nephropathy in surgeries
such as renal transplantation or partial nephrectomy, damaging renal function through …

Manganese (Mn) overexposure has been associated with the development of neurological
damage reminiscent of Parkinson's disease, while the underlying mechanisms have yet to …

Background Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly
affects exocrine glands. Previous studies have demonstrated that upregulated interferon …

Ferroptosis, a recently identified type of non-apoptotic cell death, triggers the elimination of
cells in the presence of lipid peroxidation and in an iron-dependent manner. Indeed …

Ferroptosis, a unique form of programmed cell death, is initiated by an excess of iron
accumulation and lipid peroxidation-induced damage. There is a growing body of evidence …

Heart failure (HF) and chronic kidney disease (CKD) are associated with high mortality. In
both disorders, impaired iron homeostasis, mostly in the form of a functional iron deficiency …