Cisplatin: The first metal based anticancer drug

S Ghosh - Bioorganic chemistry, 2019 - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …

Cisplatin in cancer treatment

AMP Romani - Biochemical pharmacology, 2022 - Elsevier
Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …

[HTML][HTML] Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple-negative, early high-risk and locally advanced breast …

L Gianni, CS Huang, D Egle, B Bermejo, C Zamagni… - Annals of …, 2022 - Elsevier
Background High-risk triple-negative breast cancers (TNBCs) are characterized by poor
prognosis, rapid progression to metastatic stage and onset of resistance to chemotherapy …

Cisplatin in cancer therapy: molecular mechanisms of action

S Dasari, PB Tchounwou - European journal of pharmacology, 2014 - Elsevier
Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known
chemotherapeutic drug. It has been used for treatment of numerous human cancers …

Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on …

WM Sikov, DA Berry, CM Perou, B Singh… - Journal of clinical …, 2015 - ascopubs.org
Purpose One third of patients with triple-negative breast cancer (TNBC) achieve pathologic
complete response (pCR) with standard neoadjuvant chemotherapy (NACT). CALGB 40603 …

Carbon nanotubes for delivery of small molecule drugs

BS Wong, SL Yoong, A Jagusiak, T Panczyk… - Advanced drug delivery …, 2013 - Elsevier
In the realm of drug delivery, carbon nanotubes (CNTs) have gained tremendous attention
as promising nanocarriers, owing to their distinct characteristics, such as high surface area …

Cellular processing of platinum anticancer drugs

D Wang, SJ Lippard - Nature reviews Drug discovery, 2005 - nature.com
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …

TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer

LA Carey, HS Rugo, PK Marcom, EL Mayer… - Journal of clinical …, 2012 - ascopubs.org
Purpose Epidermal growth factor receptor (EGFR) is a targetable receptor frequently
overexpressed in basal-like breast cancer, which comprises most triple-negative breast …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

[HTML][HTML] Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents

NAG Dos Santos, RS Ferreira… - Food and chemical …, 2020 - Elsevier
Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …