Cisplatin: The first metal based anticancer drug
S Ghosh - Bioorganic chemistry, 2019 - Elsevier
Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …
and widely used drugs for the treatment of various solid cancers such as testicular, ovarian …
Cisplatin in cancer treatment
AMP Romani - Biochemical pharmacology, 2022 - Elsevier
Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …
[HTML][HTML] Pathologic complete response (pCR) to neoadjuvant treatment with or without atezolizumab in triple-negative, early high-risk and locally advanced breast …
L Gianni, CS Huang, D Egle, B Bermejo, C Zamagni… - Annals of …, 2022 - Elsevier
Background High-risk triple-negative breast cancers (TNBCs) are characterized by poor
prognosis, rapid progression to metastatic stage and onset of resistance to chemotherapy …
prognosis, rapid progression to metastatic stage and onset of resistance to chemotherapy …
Cisplatin in cancer therapy: molecular mechanisms of action
S Dasari, PB Tchounwou - European journal of pharmacology, 2014 - Elsevier
Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known
chemotherapeutic drug. It has been used for treatment of numerous human cancers …
chemotherapeutic drug. It has been used for treatment of numerous human cancers …
Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on …
Purpose One third of patients with triple-negative breast cancer (TNBC) achieve pathologic
complete response (pCR) with standard neoadjuvant chemotherapy (NACT). CALGB 40603 …
complete response (pCR) with standard neoadjuvant chemotherapy (NACT). CALGB 40603 …
Carbon nanotubes for delivery of small molecule drugs
In the realm of drug delivery, carbon nanotubes (CNTs) have gained tremendous attention
as promising nanocarriers, owing to their distinct characteristics, such as high surface area …
as promising nanocarriers, owing to their distinct characteristics, such as high surface area …
Cellular processing of platinum anticancer drugs
D Wang, SJ Lippard - Nature reviews Drug discovery, 2005 - nature.com
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …
cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the …
TBCRC 001: randomized phase II study of cetuximab in combination with carboplatin in stage IV triple-negative breast cancer
Purpose Epidermal growth factor receptor (EGFR) is a targetable receptor frequently
overexpressed in basal-like breast cancer, which comprises most triple-negative breast …
overexpressed in basal-like breast cancer, which comprises most triple-negative breast …
Tumor metastasis: Mechanistic insights and therapeutic interventions
M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …
[HTML][HTML] Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents
NAG Dos Santos, RS Ferreira… - Food and chemical …, 2020 - Elsevier
Cisplatin has dramatically improved the survival rate of cancer patients, but it has also
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …
increased the prevalence of hearing and neurological deficits in this population. Cisplatin …