Research tests for the diagnosis of tuberculosis infection

T Alonzi, F Repele, D Goletti - Expert Review of Molecular …, 2023 - Taylor & Francis
Introduction Despite huge efforts, tuberculosis (TB) is still a major public health threat
worldwide, it is estimated that a quarter of the global population is infected by …

[HTML][HTML] Recent nanoengineered diagnostic and therapeutic advancements in management of Sepsis

M Soni, M Handa, KK Singh, R Shukla - Journal of Controlled Release, 2022 - Elsevier
COVID-19 acquired symptoms have affected the worldwide population and increased the
load of Intensive care unit (ICU) patient admissions. A large number of patients admitted to …

Clinical validation of a multiplex droplet digital PCR for diagnosing suspected bloodstream infections in ICU practice: a promising diagnostic tool

J Wu, B Tang, Y Qiu, R Tan, J Liu, J Xia, J Zhang… - Critical Care, 2022 - Springer
Abstract Background Droplet digital PCR (ddPCR) has emerged as a promising tool of
pathogen detection in bloodstream infections (BSIs) in critical care medicine. However …

Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

JF Bermejo-Martin, N García-Mateo, A Motos… - The Lancet …, 2023 - thelancet.com
Background The contribution of the virus to the pathogenesis of severe COVID-19 is still
unclear. We aimed to evaluate associations between viral RNA load in plasma and host …

Rapid detection of multiple resistance genes to last-resort antibiotics in Enterobacteriaceae pathogens by recombinase polymerase amplification combined with …

C Lu, J Wang, L Pan, X Gu, W Lu, D Chen… - Frontiers in …, 2023 - frontiersin.org
The worrying emergence of multiple resistance genes to last-resort antibiotics in food
animals and human populations throughout the food chain and relevant environments has …

Clinical application of a multiplex droplet digital PCR in the rapid diagnosis of children with suspected bloodstream infections

W Liu, C Wang, F Pan, J Shao, Y Cui, D Han, H Zhang - Pathogens, 2023 - mdpi.com
Droplet digital PCR (ddPCR) recently has been shown to be a potential diagnostic tool for
adults with bloodstream infections (BSIs); however, its application in children remains …

Immune regulator retinoic acid-inducible gene I (RIG-I) in the pathogenesis of cardiovascular disease

H Wang, J Yin, X Gu, W Shao, Z Jia, H Chen… - Frontiers in …, 2022 - frontiersin.org
Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor that contains
two CARD domains, an RNA helicase domain, and a C-terminal domain. RIG-I initiates …

FGF15 protects septic mice by inhibiting inflammation and modulating Treg responses

X Li, Z Zhu, Z Xia, B Xu - Journal of Inflammation Research, 2022 - Taylor & Francis
Background Fibroblast growth factor 15 (FGF15) through its FGF-receptor (FGFR)-4 inhibits
hepatic inflammation. The current study aimed at investigating whether FGF15 could inhibit …

Digital PCR as a highly sensitive diagnostic tool: A review

KV Kopylova, EW Kasparov, IV Marchenko… - Molecular Biology, 2023 - Springer
Digital PCR (dPCR) is a nucleic acid quantification method that is widely used in genetic
analysis. One of the most significant advantages of dPCR over other methods is the …

Reporter emission multiplexing in digital PCRs (REM-dPCRs): direct quantification of multiple target sequences per detection channel by population specific reporters

S Calabrese, AM Markl, M Neugebauer, SJ Krauth… - Analyst, 2023 - pubs.rsc.org
Digital PCRs (dPCRs) are widely used methods for the detection and quantification of rare
abundant sequences relevant to fields such as liquid biopsy or oncology. In order to …