An uncertainty factor of 100 is used to derive health-based guidance values for human
intakes of chemicals based on data from studies in animals. The 100-fold factor comprises …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Despite the clinical use of piperacillin
for more than two decades, there are still contradictory reports whether or not the elimination …

Abstract Piperacillin-tazobactam (PIP-TAZ) is commonly used to treat intraabdominal
infections; however, its penetration into abdominal sites is unclear. A pharmacokinetic …

In situ IR was used to precisely prepare high-purity diphenylmethyl 6α-bromopenicillanate 8,
a key intermediate of tazobactam. 8 was obtained when 6α-bromopenicillanic acid 2 reacted …

ABSTRACT A population pharmacokinetic (PK) analysis was conducted to determine if
piperacillin and tazobactam exhibited linear or nonlinear PKs and if incremental changes in …

Background: Population pharmacokinetic-pharmacodynamic (PKPD) modeling and
simulations were applied to identify optimal dosage regimens for antibiotics. As the …

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five
patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was …

Se presentan en este artículo los resultados obtenidos en desarrollo y validación de una
metodología analítica para la cuantificación simultánea de piperacilina sódica y tazobactam …

In order to conceal the unpleasant smell penicillin V potassium, and meet the needs of
children, we deal with preparation of penicillin V potassium by microencapsulated process …

Piperacillin-tazobactam was administered as a single dose (4.5 g intravenous) to five
patients with stabilized external pancreatic fistula. The penetration into pancreatic juice was …