Upon entering the biological milieu, nanomedicines swiftly interact with the surrounding
tissue fluid, subsequently being enveloped by a dynamic interplay of biomacromolecules …

Precise diagnosis and treatment of tumors currently still face considerable challenges due to
the development of highly degreed heterogeneity in the dynamic evolution of tumors. With …

Lipid nanoparticles (LNPs) have become the dominant drug delivery technology in industry,
holding the promise to deliver RNA to up or downregulate any protein of interest. LNPs …

PEGylated cholesterol-containing liposomes (Chol-PEG-lipo) have been widely used as a
drug carrier for their good stealth property in blood circulation where cholesterol maintains …

The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral,
intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate …

Highlights•Nanoparticle (NP)-protein corona (PC) plays an important role in NP
biodistribution.•This review discusses impact and mechanisms of PC on tissue distribution of …

Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction,
synovitis, and osteophyte formation. Diseasemodifying treatments for OA are currently …

Background The M1/M2 polarization of intestinal macrophages exerts an essential function
in the pathogenesis of ulcerative colitis (UC), which can be adjusted to alleviate the UC …

The design of intracellular delivery systems for protein drugs remains a challenge due to
limited delivery efficacy and serum stability. Herein, we propose a reversible assembly …

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in the spectrum of
brain tumors, primarily due to the blood–brain barrier (BBB) that hinders effective treatment …