NAD+, a pivotal coenzyme central to metabolism, exhibits a characteristic decline with age.
In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that …

Chronic elevation of blood glucose at first causes relatively minor changes to the neural and
vascular components of the retina. As the duration of hyperglycemia persists, the nature and …

Sleep deprivation (SD) leads to impaired intestinal barrier function and intestinal flora
disorder, especially a reduction in the abundance of the next generation of probiotic …

The circadian clock influences a wide range of biological process and controls numerous
aspects of physiology to adapt to the daily environmental changes caused by Earth's …

Sleep is essential to animals with circadian rhythms. Sleep deprivation causes serious
pathophysiological consequences, such as DNA damage and oxidative stress …

Circadian disruption predicts poor cancer prognosis, yet how circadian disruption is sensed
in sleep-deficiency (SD)-enhanced tumorigenesis remains obscure. Here, we show fatty …

Microglia are versatile regulators in brain development and disorders. Emerging evidence
links microRNA (miRNA)-mediated regulation to microglial function; however, the exact …

Here we presented an electrophysiological dataset collected from layer V of the primary
motor cortex (M1) and the corresponding behavior dataset from normal and hemi-parkinson …

Background Sleep loss is a common public health problem that causes hyperalgesia,
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …

Despite breakthroughs in modern medical care, the incidence of cardiovascular disease
(CVD) is even more prevalent globally. Increasing epidemiologic evidence indicates that …