Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-
genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can …

Mounting evidence from clinical and epidemiological studies suggests that lycopene, the
most abundant carotenoid in tomatoes, may be beneficial in the prevention or treatment of …

Tamoxifen (TAM) resistance has indicated a significant challenge during endocrine therapy
for hormone-sensitive breast cancer. Thus, it is significant to elucidate the molecular events …

Cancer remains one of the most challenging diseases despite significant advances of early
diagnosis and therapeutic treatments. Cancerous tumors are composed of various cell types …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …

Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Hepatocellular carcinoma (HCC), one of the most common tumours worldwide, is one of the
main causes of mortality in cancer patients. There are still numerous problems hindering its …

Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …

Cancer is a major cause of morbidity and mortality worldwide due to its ability to evade
immune surveillance and metastasize from its origin to a secondary point of contact. Though …