Slices of developing brain tissue can be grown for several weeks as socalled organotypic
slice cultures. Here we summarize and review studies using hippocampal slice cultures to …

Intraocular pressure-sensitive retinal ganglion cell degeneration is a hallmark of glaucoma,
the leading cause of irreversible blindness. Here, we used RNA-sequencing and …

Background Several reported effects of acamprosate within the glutamatergic system could
result from interactions with metabotropic glutamate receptors (mGluRs). The following …

Background: We recently reported that the sodium salt of acamprosate (Na‐acamprosate)
demonstrates the characteristics of an antagonist at metabotropic glutamate type 5 receptors …

Long-term intake of ethanol produces adaptive alterations in multiple transmitter systems in
the hippocampal formation that likely contribute to ethanol withdrawal-induced seizure and …

Background: Long‐term ethanol use and long‐term tobacco use frequently occur together,
which suggests concurrent dependence on ethanol and nicotine. Consequences of this form …

Cytosolic H+ buffering plays a major role for shaping intracellular H+ shifts and hence for the
availability of H+ for biochemical reactions and acid/base‐coupled transport processes. H+ …

Background: Long‐term ethanol dependence results in neuronal adaptation that likely
contributes to ethanol withdrawal‐induced central nervous system excitability and …

Neuronal accumulation of excess Ca2+ has been implicated in cellular death following
several forms of physical and chemotoxic insult. Recent studies have suggested that …

Seeking neutral sphingomyelinase inhibitors, we designed and synthesized hydrolytically
stable analogues of sphingomyelin. These novel analogues replace the phosphodiester …