A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae

M Li, H Jiang, Y Hao, K Du, H Du, C Ma, H Tu… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Radix Rehmanniae (RR) is the tuber root of
Rehmannia glutionsa Libosch, which was firstly recorded in Shennong's Classic of Materia …

Effect of Chinese herbal medicine on Alzheimer's disease

MJR Howes, R Fang, PJ Houghton - International review of neurobiology, 2017 - Elsevier
Alzheimer's disease (AD) is reaching epidemic proportions yet treatment strategies are
limited and are restricted to providing symptomatic relief for the cognitive and behavioral and …

Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling

H Wang, H Ran, Y Yin, X Xu, B Jiang, S Yu… - Acta Pharmacologica …, 2022 - nature.com
Neurovascular unit (NVU) is organized multi-cellular and multi-component networks that are
essential for brain health and brain homeostasis maintaining. Neurovascular unit …

Catalpol protects vascular structure and promotes angiogenesis in cerebral ischemic rats by targeting HIF-1α/VEGF

H Wang, X Xu, Y Yin, S Yu, H Ren, Q Xue, X Xu - Phytomedicine, 2020 - Elsevier
Background The initial factor in the occurrence, development, and prognosis of cerebral
ischemia is vascular dysfunction in the brain, and vascular remodeling of the brain is the key …

Catalpol: a potential therapeutic for neurodegenerative diseases

B Jiang, RF Shen, J Bi, XS Tian… - Current Medicinal …, 2015 - ingentaconnect.com
Neurodegenerative disorders, eg, Alzheimer's disease (AD) and Parkinson's disease (PD)
are characterized by the progressive loss of neurons and subsequent cognitive decline …

Jian-Yan-Ling capsules ameliorate cognitive impairment in mice with D-galactose-induced senescence and inhibit the oxidation-induced apoptosis of HT22 …

Q Lou, XE Meng, C Wei, J Tong, Y Chen, M Li… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance The Jian-Yan-Ling (JYL) capsule is a famous anti-
aging Chinese patent medicine. It is applied mainly to delay senescence to improve …

Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats' stroke model

W Dong, Y Xian, W Yuan, Z Huifeng, W Tao… - Journal of …, 2016 - Elsevier
Ethnobotanical relevance Catalpol is the main active component of the radix from
Rehmannia glutinosa Libosch, which has pleiotropic protective effects in neurodegenerative …

Effects of catalpol on Alzheimer's disease and its mechanisms

H Chen, C Deng, Z Meng… - … Based Complementary and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a degenerative disease of the central nervous system
characterized by memory loss and cognitive dysfunction. With the increasing aging of the …

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

JM Wang, LH Yang, YY Zhang, CL Niu, Y Cui… - Physiology & …, 2015 - Elsevier
Catalpol, a major compound in Rehmannia glutinosa with both medicinal and nutritional
values, has been previously confirmed to shorten the duration of immobility in mice exposed …

Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: a snapshot of their underlying mechanisms

X Zhang, K Liu, M Shi, L Xie, M Deng, H Chen… - Brain Research Bulletin, 2021 - Elsevier
Rehmannia glutinosa, the fresh or dried root of Rehmannia glutinosa (Gaertn.) Libosch. ex
Fisch. & Mey., and Gardenia, the fruit of Gardenia jasminoides Ellis from Rubiaceae, both …