Wnt signaling is essential for embryonic development, influencing processes such as axis
formation, cell proliferation and differentiation, cell fate decisions, and axon guidance. It also …

Activation of the Wnt pathway lies at the core of many human cancers. Wnt and
macropinocytosis are often active in the same processes, and understanding how Wnt …

Abstract An undisclosed polysaccharide, BCP80–2, was isolated from Belamcanda
chinensis (L.) DC. Structural investigation revealed that BCP80–2 consists of ten …

Simple Summary Breast cancer that has metastasized to other parts of the body still has a
high incidence and mortality rate. Furthermore, treating metastatic breast cancer remains a …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression
in various tumors and is associated with a poor prognosis. FAK activation promotes tumor …

Anticopalic acid (ACP), a labdane type diterpenoid obtained from Kaempferia elegans
rhizomes, together with 21 semi-synthetic derivatives, were evaluated for their cancer …

Tumor metastasis is a major concern in cancer therapy. In this context, focal adhesion
kinase (FAK) gene overexpression, which mediates cancer cell migration and invasion, has …

Oral carcinoma is the sixth most common cancer globally, with one death occurring every
hour. Focal adhesion kinase (FAK) is an intercellular protein tyrosine kinase, a key indicator …

Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are rare primary
malignant liver cancers in children and young adults. HB is the most common and accounts …

In this study, twenty-one novel 2, 4-diaminopyrimidine cinnamyl derivatives as inhibitors
targeting FAK were designed and synthesized based on the structure of TAE-226, and the …