Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study
J Gao, J Cheng, W Xie, P Zhang, X Liu… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction FAK, a nonreceptor cytoplasmic tyrosine kinase, plays a crucial role in tumor
metastasis, drug resistance, tumor stem cell maintenance, and regulation of the tumor …
metastasis, drug resistance, tumor stem cell maintenance, and regulation of the tumor …
Complexity of progranulin mechanisms of action in mesothelioma
Background Mesothelioma is an aggressive disease with limited therapeutic options. The
growth factor progranulin plays a critical role in several cancer models, where it regulates …
growth factor progranulin plays a critical role in several cancer models, where it regulates …
Molecular docking, molecular dynamics simulations, and free energy calculation insights into the binding mechanism between vs-4718 and focal adhesion kinase
M Shi, T Chen, S Wei, C Zhao, X Zhang, X Li… - ACS …, 2022 - ACS Publications
Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that plays an
important role in many carcinomas. Thus, the targeting of FAK by small molecules is …
important role in many carcinomas. Thus, the targeting of FAK by small molecules is …
Inhibition of focal adhesion kinase 2 results in a macrophage polarization shift to M2 which attenuates local and systemic inflammation and reduces heterotopic …
Introduction Heterotopic ossification (HO) is a complex pathology often observed in combat
injured casualties who have sustained severe, high energy polytraumatic extremity injuries …
injured casualties who have sustained severe, high energy polytraumatic extremity injuries …
[PDF][PDF] 藤龙补中汤对大肠癌LoVo 细胞失巢凋亡的作用及机制
王双双, 郑佳露, 陈锦芳, 邬世威… - 中国中西医结合消化 …, 2023 - zxyxh.whuhzzs.com
目的: 观察藤龙补中汤对人大肠癌LoVo 细胞失巢凋亡的作用及机制. 方法: 将藤龙补中汤作用于
悬浮生长的LoVo 细胞, CCK-8 试剂检测细胞增殖; 试剂盒检测失巢凋亡, Caspases …
悬浮生长的LoVo 细胞, CCK-8 试剂检测细胞增殖; 试剂盒检测失巢凋亡, Caspases …
Focal adhesion kinase activation by calcium‐dependent calpain is involved in chronic lymphocytic leukaemia cell aggressiveness
F Severin, N Mouawad, E Ruggeri… - British Journal of …, 2023 - Wiley Online Library
Signalling events downstream the B‐cell receptor (BCR) are central for the survival and
progression of chronic lymphocytic leukaemia (CLL) cells. Focal adhesion kinase (FAK) …
progression of chronic lymphocytic leukaemia (CLL) cells. Focal adhesion kinase (FAK) …
The Effect of Adipocyte-Secreted Factors in Activating Focal Adhesion Kinase-Mediated Cell Signaling Pathway towards Metastasis in Breast Cancer Cells
N Mubtasim, L Gollahon - International Journal of Molecular Sciences, 2023 - mdpi.com
Obesity-associated perturbations in the normal secretion of adipocytokines from white
adipocytes can drive the metastatic progression of cancer. However, the association …
adipocytes can drive the metastatic progression of cancer. However, the association …
MSC-1186, a highly selective pan-SRPK inhibitor based on an exceptionally decorated benzimidazole-pyrimidine core
M Schröder, M Leiendecker, U Grädler… - Journal of Medicinal …, 2022 - ACS Publications
The highly conserved catalytic sites in protein kinases make it difficult to identify ATP
competitive inhibitors with kinome-wide selectivity. Serendipitously, during a dedicated …
competitive inhibitors with kinome-wide selectivity. Serendipitously, during a dedicated …
On the value of in vitro cell systems for mechanobiology from the perspective of yes-associated protein/transcriptional Co-activator with a PDZ-binding motif and focal …
T Steinberg, MP Dieterle, I Ramminger, C Klein… - International Journal of …, 2023 - mdpi.com
Mechanobiology comprises how cells perceive different mechanical stimuli and integrate
them into a process called mechanotransduction; therefore, the related mechanosignaling …
them into a process called mechanotransduction; therefore, the related mechanosignaling …
Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3β signalling
Z Xu, L Huang, T Zhang, Y Liu, F Fang… - Oncology …, 2022 - spandidos-publications.com
Cervical cancer is one of the most lethal malignancies of the female reproductive system.
Shikonin, a naphthoquinone pigment extracted from the traditional medicinal herb …
Shikonin, a naphthoquinone pigment extracted from the traditional medicinal herb …