Introduction FAK, a nonreceptor cytoplasmic tyrosine kinase, plays a crucial role in tumor
metastasis, drug resistance, tumor stem cell maintenance, and regulation of the tumor …

Background Mesothelioma is an aggressive disease with limited therapeutic options. The
growth factor progranulin plays a critical role in several cancer models, where it regulates …

Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that plays an
important role in many carcinomas. Thus, the targeting of FAK by small molecules is …

Introduction Heterotopic ossification (HO) is a complex pathology often observed in combat
injured casualties who have sustained severe, high energy polytraumatic extremity injuries …

目的: 观察藤龙补中汤对人大肠癌LoVo 细胞失巢凋亡的作用及机制. 方法: 将藤龙补中汤作用于
悬浮生长的LoVo 细胞, CCK-8 试剂检测细胞增殖; 试剂盒检测失巢凋亡, Caspases …

Signalling events downstream the B‐cell receptor (BCR) are central for the survival and
progression of chronic lymphocytic leukaemia (CLL) cells. Focal adhesion kinase (FAK) …

Obesity-associated perturbations in the normal secretion of adipocytokines from white
adipocytes can drive the metastatic progression of cancer. However, the association …

The highly conserved catalytic sites in protein kinases make it difficult to identify ATP
competitive inhibitors with kinome-wide selectivity. Serendipitously, during a dedicated …

Mechanobiology comprises how cells perceive different mechanical stimuli and integrate
them into a process called mechanotransduction; therefore, the related mechanosignaling …

Cervical cancer is one of the most lethal malignancies of the female reproductive system.
Shikonin, a naphthoquinone pigment extracted from the traditional medicinal herb …