Lenvatinib is a clinically effective multikinase inhibitor approved for first‐line therapy of
advanced hepatocellular carcinoma (HCC). Although resistance against lenvatinib often …

The tyrosine kinase inhibitor (TKI) cabozantinib might impede the growth of the sunitinib-
resistant cell lines by targeting MET and AXL overexpression in metastatic renal cell …

Objective Caffeic acid phenethyl ester (CAPE), one of the components of propolis that is
produced by honeybees, reportedly suppresses multiple diseases, including bacterial …

The mechanical environment generated through the adhesive interaction of endothelial cells
(ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the …

The progression of diabetic kidney disease (DKD) is associated with increased fibronectin
(FN) levels in proximal tubular epithelial cells. Bioinformatics analysis showed that integrin …

In drug discovery, during the lead optimization and candidate characterization stages, novel
small molecules are frequently evaluated in a battery of in vitro pharmacology assays to …

Cancer affects millions of people and understanding the molecular mechanisms related to
disease development and progression is essential to manage the disease. Post …

Covalent kinase inhibitors (CKIs) have recently garnered considerable attention, yet the
rational design of CKIs continues to pose a great challenge. In the discovery of CKIs …

Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck
squamous cell carcinomas (HNSCC). Rho-associated kinase1 (ROCK1) is considered to …

FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance
development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment …