DCUN1D1 and neddylation: Potential targets for cancer therapy
JD Paccez, CLM Foret, JF de Vasconcellos… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Cancer affects millions of people and understanding the molecular mechanisms related to
disease development and progression is essential to manage the disease. Post …
disease development and progression is essential to manage the disease. Post …
Rho-associated kinase1 promotes laryngeal squamous cell carcinoma tumorigenesis and progression via the FAK signaling pathway
L Yang, P Qiao, J Zhang, S Huang, A Hu - Discover Oncology, 2022 - Springer
Laryngeal squamous cell carcinoma (LSCC) is one of the most common head and neck
squamous cell carcinomas (HNSCC). Rho-associated kinase1 (ROCK1) is considered to …
squamous cell carcinomas (HNSCC). Rho-associated kinase1 (ROCK1) is considered to …
Dynamics Playing a Key Role in the Covalent Binding of Inhibitors to Focal Adhesion Kinase
Y Liu, J Tan, S Hu, M Hussain, C Qiao… - Journal of Chemical …, 2024 - ACS Publications
Covalent kinase inhibitors (CKIs) have recently garnered considerable attention, yet the
rational design of CKIs continues to pose a great challenge. In the discovery of CKIs …
rational design of CKIs continues to pose a great challenge. In the discovery of CKIs …
A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
M Xu, X Gu, C Li, L Pan, Z Zhu, M Fan, Y Zhao… - Acta Pharmacologica …, 2024 - nature.com
FAK (focal adhesion kinase) is widely involved in cancer growth and drug resistance
development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment …
development. Thus, FAK inhibition has emerged as an effective strategy for tumor treatment …
Photoactivatable substrates show diverse phenotypes of leader cells in collective migration when moving along different extracellular matrix proteins
SA Abdellatef, F Bard, J Nakanishi - Biomaterials Science, 2024 - pubs.rsc.org
In cancer metastasis, collectively migrating clusters are discriminated into leader and
follower cells that move through extracellular matrices (ECMs) with different characteristics …
follower cells that move through extracellular matrices (ECMs) with different characteristics …
A review on the role of gamma-butyrobetaine hydroxylase 1 antisense RNA 1 in the carcinogenesis and tumor progression
J Hu, J Liu, S Zhou, H Luo - Cancer Cell International, 2023 - Springer
Gamma-butyrobetaine hydroxylase 1 antisense RNA 1 (BBOX1-AS1), located on human
chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic …
chromosome 11 p14, emerges as a critical player in tumorigenesis with diverse oncogenic …
Development of a Novel, Potent, and Selective Sialyltransferase Inhibitor for Suppressing Cancer Metastasis
HE Tsai, CL Chen, TT Chang, CW Fu… - International Journal of …, 2024 - mdpi.com
Sialyltransferase-catalyzed membrane protein and lipid glycosylation plays a vital role as
one of the most abundant post-translational modifications and diversification reactions in …
one of the most abundant post-translational modifications and diversification reactions in …
[HTML][HTML] N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer
Y Zhang, F Zhou, MY Zhang, LN Feng… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND N6-methyladenosine (m6A) methylation modification exists in Epstein-Barr
virus (EBV) primary infection, latency, and lytic reactivation. It also modifies EBV latent genes …
virus (EBV) primary infection, latency, and lytic reactivation. It also modifies EBV latent genes …
A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events
JA Estep, LO Sun, MM Riccomagno - Heliyon, 2023 - cell.com
Abstract Integrin Adhesion Complexes (IACs) serve as links between the cytoskeleton and
extracellular environment, acting as mechanosensing and signaling hubs. As such, IACs …
extracellular environment, acting as mechanosensing and signaling hubs. As such, IACs …
Widely-targeted in silico and in vitro evaluation of veratrum alkaloid analogs as FAK inhibitors and dual targeting of FAK and Hh/SMO pathways for cancer therapy: A …
DA Mosoh - International Journal of Biological Macromolecules, 2024 - Elsevier
Abstract Focal Adhesive Kinase (FAK), a key player in aggressive cancers, mediates signals
crucial for progression, invasion, and metastasis. Despite advances in targeted therapies …
crucial for progression, invasion, and metastasis. Despite advances in targeted therapies …