[HTML][HTML] Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
Autophagy in neurons
AKH Stavoe, ELF Holzbaur - Annual review of cell and …, 2019 - annualreviews.org
Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …
aggregates. Autophagy is particularly important in neurons, which are terminally …
The role of autophagy in neurodegenerative disease
RA Nixon - Nature medicine, 2013 - nature.com
Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …
and eliminate damaged organelles and protein aggregates. These substrates reach …
Autophagy induction as a therapeutic strategy for neurodegenerative diseases
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
Neuronal autophagy and mitophagy in Parkinson's disease
Autophagy is the process by which cells can selectively or non-selectively remove damaged
proteins and organelles. As the cell's main means of sequestering damaged mitochondria …
proteins and organelles. As the cell's main means of sequestering damaged mitochondria …
[HTML][HTML] Therapeutic potential of autophagy-enhancing agents in Parkinson's disease
TE Moors, JJM Hoozemans, A Ingrassia… - Molecular …, 2017 - Springer
Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …
Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease
KE Murphy, AM Gysbers, SK Abbott, N Tayebi, WS Kim… - Brain, 2014 - academic.oup.com
Heterozygous mutations in GBA1, the gene encoding lysosomal glucocerebrosidase, are
the most frequent known genetic risk factor for Parkinson's disease. Reduced …
the most frequent known genetic risk factor for Parkinson's disease. Reduced …
Pathogenic lysosomal depletion in Parkinson's disease
B Dehay, J Bové, N Rodríguez-Muela… - Journal of …, 2010 - Soc Neuroscience
Mounting evidence suggests a role for autophagy dysregulation in Parkinson's disease
(PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles …
(PD). The bulk degradation of cytoplasmic proteins (including α-synuclein) and organelles …
[HTML][HTML] What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases
CT Chu - Neurobiology of disease, 2019 - Elsevier
Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation
system has been repudiated, due in part to important discoveries in neurodegenerative …
system has been repudiated, due in part to important discoveries in neurodegenerative …