Fibrosis progression in the lung commonly results in impaired functional gas exchange,
respiratory failure, or even death. In addition to the aberrant activation and differentiation of …

Background Macrophages are heterogenous phagocytic cells with an important role in the
innate immunity. They are, also, significant contributors in the adaptive immune system …

Macrophages populate every organ during homeostasis and disease, displaying features of
tissue imprinting and heterogeneous activation. The disconnected picture of macrophage …

Ontologically distinct populations of macrophages differentially contribute to organ fibrosis
through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing …

A diverse group of toxicants has been identified that cause injury to the lung including gases
(eg, ozone, chlorine), particulates/aerosols (eg, diesel exhaust, fly ash, other combustion …

Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …

Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …

Systemic sclerosis (SSc) is a severe auto-immune disease, characterized by vasculopathy
and fibrosis of connective tissues. SSc has a high morbidity and mortality and unfortunately …

Catecholamines and adipokines function as hormones; catecholamines as
neurotransmitters in the sympathetic nervous system, and adipokines as mediators of …

Abstract The Resistin-Like Molecules (RELM) α, β, and γ and their namesake, resistin, share
structural and sequence homology but exhibit significant diversity in expression and function …