In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …

Forty-four bicyclo ((aryl) methyl) benzamides, acting as glycine transporter type 1 (GlyT1)
inhibitors, are developed using molecular modeling techniques. QSAR models generated by …

N-methyl-D-aspartate (NMDA) receptor hypofunction leading to neural network dysfunction
is thought to play an important role in the pathophysiology of cognitive impairment …

Aquaporins (AQPs) play critical physiological roles in water balance in the central nervous
system (CNS). Aquaporin-4 (AQP4), the principal aquaporin expressed in the CNS, has …

Glycine is a small molecule. It cannot change its conformation and is achiral. Despite the
apparent simplicity, glycine shows endless diversity in its behavior over many phenomena. It …

Disruption of the inhibitory control provided by the glycinergic system is one of the major
mechanisms underlying chronic pain. In line with this concept, recent studies have provided …

Cognitive dysfunction is one of the core symptoms in schizophrenia, and it is predictive of
functional outcomes and therefore useful for treatment targets. Rather than improving …

The accurate function of the central nervous system (CNS) depends of the consonance of
multiple genetic programs and external signals during the ontogenesis. A variety of …

Background & aims Carnitine biosynthesis has been related to fatty acid oxidation, a
process probably exerting neuroprotective effects. However, the role of carnitine …