Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Basement membranes provide structural support to epithelium, endothelium, muscles, fat
cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate …

Models of liver fibrosis, which include cell culture models, explanted and biopsied human
material, and experimental animal models, have demonstrated that liver fibrosis is a highly …

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

In 1876, von Kupffer described liver Sternzellen (star-shaped cells). The functions of these
cells remained enigmatic for 75 years until Ito observed lipid-containing perisinusoidal cells …

Myofibroblasts are a unique group of smooth-muscle-like fibroblasts that have a similar
appearance and function regardless of their tissue of residence. Through the secretion of …

Fibrosis is a highly conserved wound healing response and represents the final common
pathway of virtually all chronic inflammatory injuries. Over the past 3 decades detailed …

Liver fibrosis is the most common final outcome for chronic liver diseases. The complex
pathogenesis includes hepatic parenchymal damage as a result of a persistent noxe …