Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the
сoronavirus disease 2019 have become a global health threat. At the height of the …

Objective COVID-19 might cause neuroinflammation in the brain, which could decrease
neurocognitive function. We aimed to evaluate the causal associations and genetic overlap …

Imaging genetics is a crucial tool that is applied to explore potentially disease-related
biomarkers, particularly for neurodegenerative diseases (NDs). With the development of …

Background In order to utilize polygenic risk scores (PRSs) for Alzheimer's disease (AD) in a
meaningful way, influential factors (ie training set) and prediction across groups such as …

Background Cognitive decline, and more specifically Alzheimer's disease, continues to
increase in prevalence globally, with few, if any, adequate preventative approaches. Several …

American Indians (AI) demonstrate the highest rates of both suicidal behaviors (SB) and
alcohol use disorders (AUD) among all ethnic groups in the US. Rates of suicide and AUD …

Importance Brain aging elicits complex neuroanatomical changes influenced by multiple
age-related pathologies. Understanding the heterogeneity of structural brain changes in …

Background Large-scale cohort and epidemiological studies suggest that PTSD confers risk
for dementia in later life but the biological mechanisms underlying this association remain …

Gouveia and colleagues (2022) 1 conducted a genome-wide association study (GWAS) of a
polygenic risk score (PRS)-derived phenotype (N= 37,784), in which they identified 246 …