Opioids are powerful drugs that usurp and overpower the reward function of endogenous
opioids and engage dramatic tolerance and withdrawal via molecular and neurocircuitry …

Aberrant patterns of brain functional connectivity in the default mode network (DMN) have
been observed across different classes of substance use disorder (SUD) and are associated …

Public health authorities have described, with growing alarm, an unprecedented increase in
morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to …

Abstract The United States opioid epidemic is a nationwide public health crisis. Initially
driven by increased consumption and availability of pharmaceutical opioids, an increasing …

Conduct disorder is a childhood behaviour disorder that is characterized by persistent
aggressive or antisocial behaviour that disrupts the child's environment and impairs his or …

Background Prevalence rates of opioid use disorder (OUD) have increased dramatically,
accompanied by a surge of overdose deaths. While opioid dependence has been …

It is well recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

Our understanding of chronic pain involves complex brain circuits that include sensory,
emotional, cognitive and interoceptive processing. The feed-forward interactions between …

Despite intensive scientific investigation and public health imperatives, drug addiction
treatment outcomes have not significantly improved in more than 50years. Non-invasive …

The panoply of cognitive, affective, motivational, and social functions that underpin everyday
human experience requires precisely choreographed patterns of interaction between …