Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The mechanisms of how obesity contributes to the development of cardio-metabolic
diseases are not entirely understood. Obesity is frequently associated with adipose tissue …

Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic
stem and progenitor cells. Single-cell gene expression analyses of myogenesis have been …

Following acute injury, stromal cells promote tissue regeneration by a diversity of
mechanisms. Time-resolved single-cell RNA sequencing of muscle mesenchymal stromal …

Skeletal muscle regeneration involves coordinated interactions between different cell types.
Injection of platelet-rich plasma is circumstantially considered an aid to muscle repair but …

Systemic deletion of senescent cells leads to robust improvements in cognitive,
cardiovascular, and whole‐body metabolism, but their role in tissue reparative processes is …

The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging
evidence suggests that STING is important for DNA or cGAMP-induced non-canonical …

Sepsis induces immune alterations, which last for months after the resolution of illness. The
effect of this immunological reprogramming on the risk of developing cancer is unclear. Here …

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is
often linked to aging, which is characterized by the progressive loss of physiological …

Specialized pro‐resolving mediators actively limit inflammation and support tissue
regeneration, but their role in age‐related muscle dysfunction has not been explored. We …