[HTML][HTML] Immunobiography and the heterogeneity of immune responses in the elderly: a focus on inflammaging and trained immunity
Owing to its memory and plasticity, the immune system (IS) is capable of recording all the
immunological experiences and stimuli it was exposed to. The combination of type, dose …
immunological experiences and stimuli it was exposed to. The combination of type, dose …
[HTML][HTML] Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions
A Salminen - Journal of Molecular Medicine, 2021 - Springer
The functional competence of the immune system gradually declines with aging, a process
called immunosenescence. The age-related remodelling of the immune system affects both …
called immunosenescence. The age-related remodelling of the immune system affects both …
[HTML][HTML] Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy
Approximately 60% of patients with large B cell lymphoma treated with chimeric antigen
receptor (CAR) T cell therapies targeting CD19 experience disease progression, and …
receptor (CAR) T cell therapies targeting CD19 experience disease progression, and …
[HTML][HTML] Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
[HTML][HTML] Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites
Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to
infection and vaccination, while in humans, the existence and properties of TRMs remain …
infection and vaccination, while in humans, the existence and properties of TRMs remain …
BSA‐AIE nanoparticles with boosted ROS generation for immunogenic cell death immunotherapy of multiple myeloma
Z Liu, J Zhang, H Liu, H Shen, N Meng, X Qi… - Advanced …, 2023 - Wiley Online Library
The main obstacle of multiple myeloma (MM) therapy is the compromised immune
microenvironment, which leads to MM relapses and extramedullary disease progression. In …
microenvironment, which leads to MM relapses and extramedullary disease progression. In …
[HTML][HTML] Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV)
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
infection and responds poorly to immune checkpoint blockade. Here, we examined the …
[HTML][HTML] Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
M Ilander, U Olsson-Strömberg, H Schlums, J Guilhot… - Leukemia, 2017 - nature.com
Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in
deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment …
deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment …
[HTML][HTML] Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy
BACKGROUND. Our understanding of phenotypic and functional signatures of CD8+ T cell
dysfunction in acute myeloid leukemia (AML) is limited. Deciphering these deranged T cell …
dysfunction in acute myeloid leukemia (AML) is limited. Deciphering these deranged T cell …
[HTML][HTML] Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia
T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of
mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common …
mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common …