Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

Schizophrenia and depression are heterogeneous disorders. The complex
pathomechanism of the diseases imply that medication responses vary across patients …

Clinical studies provide evidence that ketamine and psilocybin could be used as fast-acting
antidepressants, though their mechanisms and toxicity are still not fully understood. To …

The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …

Abstract See Schrag and Politis (doi: 10.1093/aww190) for a scientific commentary on this
article. Apathy, which can occur separately or in combination with depression and anxiety, is …

Parkinson's disease (PD) is characterized mainly by motor dysfunctions due to the
progressive loss of dopaminergic neurons. However, PD patients experience a multitude of …

Increasing evidence shows changes in gut microbiota composition in association with
psychiatric disorders, including anxiety and depression. Moreover, it has been reported that …

The International Journal of Molecular Sciences Special Issue “Serotonin in health and
diseases” covers several aspects of the multiple and still mysterious functions of serotonin (5 …

Serotonin has widespread, but computationally obscure, modulatory effects on learning and
cognition. Here, we studied the impact of optogenetic stimulation of dorsal raphe serotonin …

Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by
neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars …