BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

After fertilization, sperm and oocyte fused and gave rise to a zygote which is the beginning of
a new life. Then the embryonic development is monitored and regulated precisely from the …

Purpose Oocyte maturation defect (OOMD) is a rare cause of in vitro fertilization failure
characterized by the production of immature oocytes. Compound heterozygous or …

Antimony (Sb) is a metalloid, widely presents in the environment and associates with human
health. In this study, we aimed to decipher whether Sb exposure is harmful to female …

The subcortical maternal complex (SCMC), which is vital in oocyte maturation and
embryogenesis, consists of core proteins (NLRP5, TLE6, OOEP), non-core proteins (PADI6 …

Human reproduction is a complex process involving gamete maturation, fertilization, embryo
cleavage and development, blastocyst formation, implantation, and live birth. If any of these …

Successful reproduction in mammals requires gamete development, fertilization, and early
embryonic development. Defects in any of these processes can lead to infertility, recurrent …

Background The genotype-phenotype relationships between TUBB8 variants and female
infertility are difficult to clearly define due to the complex inheritance patterns and the highly …

Reactive oxygen species (ROS) are associated with oocyte maturation inhibition, and N‐
acetyl‐l‐cysteine (NAC) partially reduces their harmful effects. Mitochondrial E3 ubiquitin …

Recurrent pregnancy loss (RPL), often known as spontaneous miscarriages occurring two or
more times in a row, is a reproductive disease that affects certain couples. The cause of RPL …