MICU1's calcium sensing beyond mitochondrial calcium uptake
SD Kaye, S Goyani, D Tomar - … et Biophysica Acta (BBA)-Molecular Cell …, 2024 - Elsevier
The discovery of MICU1 as gatekeeper of mitochondrial calcium (m Ca 2+) entry has
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …
transformed our understanding of m Ca 2+ flux. Recent studies revealed an additional role …
[HTML][HTML] Dysregulation of calcium homeostasis in cancer and its role in chemoresistance
Globally, cancer, as a major public health concern, poses a severe threat to people's well-
being. Advanced and specialized therapies can now cure the majority of people with early …
being. Advanced and specialized therapies can now cure the majority of people with early …
[HTML][HTML] Increased vulnerability to ferroptosis in FUS-ALS
M Ismail, D Großmann, A Hermann - Biology, 2024 - mdpi.com
Simple Summary Ferroptosis is a form of regulated cell death characterized by lipid peroxide
accumulation and is involved in various disease conditions, including neurodegenerative …
accumulation and is involved in various disease conditions, including neurodegenerative …
[HTML][HTML] Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells
Y Zhang, S Shaabani, K Vowinkel… - Biomedicine & …, 2024 - Elsevier
Small conductance calcium-activated potassium (SK) channel activity has been proposed to
play a role in the pathology of several neurological diseases. Besides regulating plasma …
play a role in the pathology of several neurological diseases. Besides regulating plasma …
[HTML][HTML] MicroRNA-129-1-3p protects chicken granulosa cells from cadmium-induced apoptosis by down-regulating the MCU-mediated Ca2+ signaling pathway
M Zhu, M Yan, M Musa, Y Li, Y Zhang, X Zou - … and Environmental Safety, 2024 - Elsevier
Cadmium (Cd) is known as a female reproductive toxicant. Our previous study has shown
that Cd can influence the proliferation and cell cycle of granulosa cells and induce …
that Cd can influence the proliferation and cell cycle of granulosa cells and induce …
[HTML][HTML] Dihydropashanone Isolated from Lindera erythrocarpa, a Potential Natural Product for the Treatment of Neurodegenerative Diseases
Lindera erythrocarpa, a flowering plant native to eastern Asia, has been reported to have
neuroprotective activity. However, reports on the specific bioactive compounds in L …
neuroprotective activity. However, reports on the specific bioactive compounds in L …
[HTML][HTML] AMPK Activation by Cimicifuga racemosa Extract Ze 450 Is Associated with Metabolic Effects and Cellular Resilience against Age-Related Pathologies in …
M Günther, P Schnierle, T Rose, J Schlegel, G Boonen… - Pharmaceutics, 2024 - mdpi.com
Cimicifuga racemosa extracts (CREs) have gained well-established use for the treatment of
menopausal symptoms such as hot flushes and excessive sweating, and weight gain. While …
menopausal symptoms such as hot flushes and excessive sweating, and weight gain. While …
Increased Vulnerability against Ferroptosis in FUS‐ALS
M Ismail, D Großmann, A Hermann - 2024 - preprints.org
Ferroptosis, a regulated form of cell death characterized by iron-dependent lipid peroxide
accumulation, plays a pivotal role in various pathological conditions, including …
accumulation, plays a pivotal role in various pathological conditions, including …
Endoplasmic Reticulum-Mitochondria Contacts are apical hotspots of lipid peroxidation driving ferroptosis
P Agostinis, ML Sassano, YY Tyurina, A Diometzidou… - 2024 - researchsquare.com
Peroxidation of membrane phospholipids (PLs) is a hallmark of ferroptosis. ER and
mitochondria have been implicated in ferroptosis, but whether intracellular PL-peroxidation …
mitochondria have been implicated in ferroptosis, but whether intracellular PL-peroxidation …
Metabolic reprogramming: a new option for the treatment of spinal cord injury
J Chen, J Chen, C Yu, K Xia, B Yang, R Wang… - Neural Regeneration … - journals.lww.com
Spinal cord injuries impose a notably economic burden on society, mainly because of the
severe after effects they cause. Despite the ongoing development of various therapies for …
severe after effects they cause. Despite the ongoing development of various therapies for …