The critical functions of the human liver are coordinated through the interactions of hepatic
parenchymal and non‐parenchymal cells. Recent advances in single‐cell transcriptional …

Single-cell transcriptomics has transformed our ability to characterize cell states, but deep
biological understanding requires more than a taxonomic listing of clusters. As new methods …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …

INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

Recent studies have emphasized the importance of single-cell spatial biology, yet available
assays for spatial transcriptomics have limited gene recovery or low spatial resolution. Here …

Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however,
crucial spatial information is often lost. We present SpaOTsc, a method relying on structured …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
prevalent liver conditions that underlie the development of life-threatening cirrhosis, liver …