The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

Background & Aims The multiple vital functions of the human liver are performed by highly
specialised parenchymal and non-parenchymal cells organised in complex collaborative …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …

The liver is one of the major metabolic organs in the body, susceptible to injury caused by
various factors. In response to injury, sophisticated mechanisms are engaged to repair and …

How fully differentiated cells that experience carcinogenic insults become proliferative
cancer progenitors that acquire multiple initiating mutations is not clear. This question is of …

Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

Non‐alcoholic fatty liver disease is comprised of either simple steatosis (non‐alcoholic fatty
liver) or a more advanced inflammatory and fibrogenic stage (non‐alcoholic steatohepatitis …

Biliary Atresia is a devastating pediatric cholangiopathy affecting the bile ducts of the liver. In
this review, we describe recent progress in the understanding of liver development with a …

Single-cell RNA sequencing (scRNA-seq) has revolutionized transcriptomic studies by
providing unprecedented cellular and molecular throughputs, but spatial information of …