This paper is the thirty-eighth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2015 …

Background The kappa opioid receptor system has been revealed as a potential
pharmacotherapeutic target for the treatment of addictions to substances of abuse. Kappa …

An enantioselective [3+ 2] annulation of donor–acceptor aziridines with aldehydes has been
realized using a Nd (OTf) 3/N, N′-dioxide/LiNTf2 catalyst system, providing various chiral …

We designed and synthesized novel triplet molecules with 1, 3, 5‐trioxazatriquinane
skeletons. One class comprises double‐capped triplets with a morphinan skeleton; the other …

Structurally diverse small compounds are utilized to obtain hit compounds that have suitable
pharmacophores in appropriate three-dimensional conformations for the target drug …

The D-nor-nalfurafine derivatives, which were synthesized by contraction of the six-
membered D-ring in nalfurafine (1), had no affinity for orexin 1 receptors (OX 1 Rs). The 17N …

Abstract A novel series of 1, 3, 5‑trioxazatriquinane with multiple effective residues (TriMER)
derivatives with amino-methylene side chains was designed and synthesized based on the …

As the reports about C-homomorphinans with the seven-membered C-ring are much fewer
than those of morphinan derivatives with a six-membered C-ring, we attempted to synthesize …

We designed and synthesized of 1, 3, 5-trioxazatriquinanes with o-or p-hydroxyphenyl rings
as analogs of the κ opioid receptor agonist SYK-146 with m-hydroxyphenyl groups. Although …

The synthesis of novel adamantane-like cage compounds consisting of phosphorus, sulfur,
and carbon atoms was developed. We examined the reaction of a variety of acetophenone …