Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques
H Li, S Wang, R Kong, W Ding… - Proceedings of the …, 2016 - National Acad Sciences
Most simian–human immunodeficiency viruses (SHIVs) bearing envelope (Env)
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …
glycoproteins from primary HIV-1 strains fail to infect rhesus macaques (RMs). We …
Antiviral lectins: Selective inhibitors of viral entry
CA Mitchell, K Ramessar, BR O'Keefe - Antiviral research, 2017 - Elsevier
Many natural lectins have been reported to have antiviral activity. As some of these have
been put forward as potential development candidates for preventing or treating viral …
been put forward as potential development candidates for preventing or treating viral …
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity
K Sliepen, G Ozorowski, JA Burger, T van Montfort… - Retrovirology, 2015 - Springer
Background Presenting vaccine antigens in particulate form can improve their
immunogenicity by enhancing B cell activation. Findings We describe ferritin-based protein …
immunogenicity by enhancing B cell activation. Findings We describe ferritin-based protein …
Quantification of the impact of the HIV-1-glycan shield on antibody elicitation
While the HIV-1-glycan shield is known to shelter Env from the humoral immune response,
its quantitative impact on antibody elicitation has been unclear. Here, we use targeted …
its quantitative impact on antibody elicitation has been unclear. Here, we use targeted …
Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans
The high-mannose patch on the HIV-1 envelope (Env) glycoprotein is the epicenter for
binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for …
binding of the potent broadly neutralizing PGT121 family of antibodies, but strategies for …
Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
L He, N De Val, CD Morris, N Vora, TC Thinnes… - Nature …, 2016 - nature.com
Structures of BG505 SOSIP. 664 trimer in complex with broadly neutralizing antibodies
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …
(bNAbs) have revealed the critical role of trimeric context for immune recognition of HIV-1 …
Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design
Broadly neutralizing antibodies (bnAbs) directed to the V2 apex of the HIV envelope (Env)
trimer isolated from individual HIV-infected donors potently neutralize diverse HIV strains …
trimer isolated from individual HIV-infected donors potently neutralize diverse HIV strains …
[HTML][HTML] Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo
M Medina-Ramírez, F Garces, A Escolano… - Journal of Experimental …, 2017 - rupress.org
Induction of broadly neutralizing antibodies (bNAbs) by HIV-1 envelope glycoprotein
immunogens would be a major advance toward an effective vaccine. A critical step in this …
immunogens would be a major advance toward an effective vaccine. A critical step in this …
Structural basis for membrane anchoring of HIV-1 envelope spike
HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used
nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) …
nuclear magnetic resonance to determine an atomic structure of the transmembrane (TM) …
Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
As the sole target of broadly neutralizing antibodies (bnAbs) to HIV, the envelope
glycoprotein (Env) trimer is the focus of vaccination strategies designed to elicit protective …
glycoprotein (Env) trimer is the focus of vaccination strategies designed to elicit protective …