Vaccination with glycan-modified HIV NFL envelope trimer-liposomes elicits broadly neutralizing antibodies to multiple sites of vulnerability
V Dubrovskaya, K Tran, G Ozorowski, J Guenaga… - Immunity, 2019 - cell.com
The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope
glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein …
glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein …
Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller
Some HIV-1–infected patients develop broad and potent HIV-1 neutralizing antibodies
(bNAbs) that when passively transferred to mice or macaques can treat or prevent infection …
(bNAbs) that when passively transferred to mice or macaques can treat or prevent infection …
Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design
Broadly neutralizing antibodies (bNAbs) against HIV-1 Env V1V2 arise in multiple donors.
However, atomic-level interactions had previously been determined only with antibodies …
However, atomic-level interactions had previously been determined only with antibodies …
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations
HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor
CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env …
CD4 and coreceptor. Imaging of individual Env molecules on native virions shows Env …
Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization
The production of native-like recombinant versions of the HIV-1 envelope glycoprotein (Env)
trimer requires overcoming the natural flexibility and instability of the complex. The …
trimer requires overcoming the natural flexibility and instability of the complex. The …
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
Elicitation of broadly neutralizing antibodies (bnAbs) is a primary HIV vaccine goal. Native-
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
like trimers mimicking virion-associated spikes present nearly all bnAb epitopes and are …
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine …
Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
Human antibodies for viral infections
JE Crowe Jr - Annual review of immunology, 2022 - annualreviews.org
Antibodies have been used to prevent or treat viral infections since the nineteenth century,
but the full potential to use passive immunization for infectious diseases has yet to be …
but the full potential to use passive immunization for infectious diseases has yet to be …
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
A major obstacle to a broadly neutralizing antibody (bnAb)–based HIV vaccine is the
activation of appropriate B cell precursors. Germline-targeting immunogens must be capable …
activation of appropriate B cell precursors. Germline-targeting immunogens must be capable …
[HTML][HTML] Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies
Generation of potent antibodies by a mutation-selection process called affinity maturation is
a key component of effective immune responses. Antibodies that protect against highly …
a key component of effective immune responses. Antibodies that protect against highly …