Release of gp120 restraints leads to an entry-competent intermediate state of the HIV-1 envelope glycoproteins
Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers
[(gp120/gp41) 3] typically exist in a metastable closed conformation (state 1). Binding the …
[(gp120/gp41) 3] typically exist in a metastable closed conformation (state 1). Binding the …
Single-chain soluble BG505. SOSIP gp140 trimers as structural and antigenic mimics of mature closed HIV-1 Env
IS Georgiev, MG Joyce, Y Yang, M Sastry… - Journal of …, 2015 - Am Soc Microbiol
Similar to other type I fusion machines, the HIV-1 envelope glycoprotein (Env) requires
proteolytic activation; specifically, cleavage of a gp160 precursor into gp120 and gp41 …
proteolytic activation; specifically, cleavage of a gp160 precursor into gp120 and gp41 …
Neutralization tiers of HIV-1
The tier 2 neutralization phenotype is typical of most circulating strains and is associated
with a predominantly closed Env trimer configuration that is a high priority to target with …
with a predominantly closed Env trimer configuration that is a high priority to target with …
Germline‐targeting immunogens
In 2009, Dimitrov's group reported that the inferred germline (iGL) forms of several HIV‐1
broadly neutralizing antibodies (bNA bs) did not display measurable binding to a …
broadly neutralizing antibodies (bNA bs) did not display measurable binding to a …
The HIV glycan shield as a target for broadly neutralizing antibodies
KJ Doores - The FEBS journal, 2015 - Wiley Online Library
The HIV envelope glycoprotein (Env) is the sole target for HIV broadly neutralizing
antibodies (bnAbs). HIV Env is one of the most heavily glycosylated proteins known, with …
antibodies (bnAbs). HIV Env is one of the most heavily glycosylated proteins known, with …
Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the Env high-mannose patch
The high-mannose patch on HIV Env is a preferred target for broadly neutralizing antibodies
(bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we …
(bnAbs), but to date, no vaccination regimen has elicited bnAbs against this region. Here, we …
Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
[HTML][HTML] Immunogenicity of a new gorilla adenovirus vaccine candidate for COVID-19
S Capone, A Raggioli, M Gentile, S Battella, A Lahm… - Molecular Therapy, 2021 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic caused by the emergent severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health, and there …
respiratory syndrome coronavirus 2 (SARS-CoV-2) threatens global public health, and there …
Multi-donor longitudinal antibody repertoire sequencing reveals the existence of public antibody clonotypes in HIV-1 infection
Characterization of single antibody lineages within infected individuals has provided
insights into the development of Env-specific antibodies. However, a systems-level …
insights into the development of Env-specific antibodies. However, a systems-level …
Comparative analysis of the glycosylation profiles of membrane-anchored HIV-1 envelope glycoprotein trimers and soluble gp140
EP Go, A Herschhorn, C Gu… - Journal of …, 2015 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer, which
consists of the gp120 and gp41 subunits, is the focus of multiple strategies for vaccine …
consists of the gp120 and gp41 subunits, is the focus of multiple strategies for vaccine …