Microbes adapt their metabolism to take advantage of nutrients in their environment. Such
adaptations control specific metabolic pathways to match energetic demands with nutrient …

In recent years, genetic circuit-based regulation of metabolic flux in microbial cell factories
has received significant attention. In this review, we describe a pipeline for the design and …

Auto-regulatory feedback loops are used by cells to maintain homeostasis and to initiate
irreversible transitions between cell states. Genome-wide experimental and computational …

The abundance of proteins expressed in a particular environment are primary determinants
of an organism's phenotypic and fitness properties. However, protein synthesis is costly and …

Im Rahmen dieser Arbeit wurde der Katabolismus von Ectoinen durch das marine Bakterium
Ruegeria pomeroyi DSS-3 untersucht. Basierend auf der Hypothese eines katabolen …

Where in metabolism are individual transcription factors effective and how strong is the
impact depending on extracellular conditions? To answer these questions, we identified …

Gene expression is regulated by specific transcriptional circuits but also by the global
expression machinery as a function of growth. Simultaneous specific and global regulation …

Global energy demand, rising petroleum prices and environmental concerns have
stimulated increased efforts to develop more sustainable and cost-effective chemicals that …

A grand challenge in synthetic biology is to push the design of biomolecular circuits from
purely genetic constructs towards systems that interface different levels of the cellular …