It is widely accepted that the immune system includes molecular and cellular components
that play a role in regulating and suppressing the effector immune response in almost any …

The immune tumor microenvironment (TME) of colorectal cancer (CRC) is a crucial
contributor to disease biology, making it an important target for therapeutic intervention. The …

With the significant successes of immune checkpoint blockade and adoptive cellular
therapy, immunotherapy has now become an established treatment option to effectively treat …

Simple Summary It has been known for decades that immune T cells, especially due to their
capacity for powerful antigen-directed cytotoxicity, have become a central focus for engaging …

Negative checkpoint regulators (NCR) are intensely pursued as targets to modulate the
immune response in cancer and autoimmunity. A large variety of NCR is expressed by …

Simple Summary Low oxygen tension (hypoxia) caused by high demand of cancer cell
proliferation or standard of care therapy is a prevalent feature of solid tumors and is often …

Glioblastoma is the most common primary malignant brain tumor in adults with an overall
survival of only 14.6 months. Hypoxia is known to play a role in tumor aggressiveness but …

Recent genetic and molecular studies have indicated that the innate immune system,
especially microglia, have a crucial role in the accumulation of β-amyloid plaques in …

Introduction Although higher incidence of cancer represents a major burden for obstructive
sleep apnea (OSA) patients, the molecular pathways driving this association are not …

Paradoxically, tumor development and progression can be inhibited and promoted by the
immune system. After three stages of immune editing, namely, elimination, homeostasis and …