The rising burden of cancer worldwide calls for an alternative treatment solution. Herbal
medicine provides a very feasible alternative to western medicine against cancer. This …

Significance: Oxidative stress, an excess of reactive oxygen species (ROS) production
versus consumption, may be involved in the pathogenesis of different diseases. The only …

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …

Despite recent progress in non‐small‐cell lung cancer (NSCLC) treatment, treatment
outcomes remain poor, mainly because of treatment resistance or toxicity. Erastin is a …

Targeting the ubiquitin-proteasome pathway has emerged as a rational approach in the
treatment of human cancer. Based on positive preclinical and clinical studies, bortezomib …

Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Altering the balance between energy intake and expenditure is a potential strategy for
treating obesity and metabolic syndrome. Nonetheless, despite years of progress in …

Ubiquitin-tagged substrates are degraded by the 26S proteasome, which is a multisubunit
complex comprising a proteolytic 20S core particle capped by 19S regulatory particles,. The …

Abstract Celastrol (CEL), a plant-derived triterpenoid, is a known inhibitor of Hsp90 and NF-
κB activation pathways and has recently been suggested to be of therapeutic importance in …

Over the past ten years, proteasome inhibition has emerged as an effective therapeutic
strategy for treating multiple myeloma (MM) and some lymphomas. In 2003, Bortezomib …