Neurodegenerative diseases such as Huntington disease are devastating disorders with no
therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to …

Tumor microenvironment favors tumor cells to promote their growth and metastasis such as
migration, invasion, and angiogenesis. IL-1β, one of the inflammatory cytokines released …

Covering: January 2006 to December 2008 This article reviews the antitumor and anti-HIV
activities of naturally occurring triterpenoids, including the lupane, ursane, oleanane …

In the past 15 years, the proteasome has been validated as an anti-cancer drug target and
20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the …

In the last decade, gypsogenin has attracted widespread attention from medicinal chemists
by virtue of its prominent anti-cancer potential. Despite its late identification, gypsogenin has …

Withaferin A (WA) is a steroidal lactone purified from medicinal plant “Indian Winter Cherry”
that is widely researched for its variety of properties, including antitumor effects. However …

The molecular chaperone heat shock protein 90 (Hsp90) is required for the stabilization and
conformational maturation of various oncogenic proteins in cancer. The loading of protein …

Aberrant overexpression of nicotinamide phosphoribosyltransferase (NAMPT) has been
reported in a variety of tumor cells and is a poor prognosis factor for patient survival. It plays …

Shikonin, extracted from medicinal Chinese herb (Lithospermum erythrorhizo), was reported
to exert anti-inflammatory and anti-cancer effects both in vitro and in vivo. We have found …

Terpenoids represent a large and diverse class of naturally occurring compounds found in a
variety of fruits, vegetables and medicinal plants. Structurally some of the terpenoids are …