The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …

Study Design. Laboratory study. Objective. The aims of this study were as follows:(1) to
confirm that Substance P (SP) is expressed by nucleus pulposus (NP) and annulus fibrosus …

In most HCO 3−-secreting epithelial tissues, SLC26 Cl−/HCO 3− transporters work in concert
with the cystic fibrosis transmembrane conductance regulator (CFTR) to regulate the …

The nervous system mediates key airway protective behaviors, including cough, mucus
secretion, and airway smooth muscle contraction. Thus, its involvement and potential …

Abstract The Ca 2+ and cAMP/PKA pathways are the primary signaling systems in secretory
epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca 2+ …

A central function of epithelia is the control of the volume and electrolyte composition of
bodily fluids through vectorial transport of electrolytes and the obligatory H 2 O. In exocrine …

Chloride secretion by airway epithelial cells is defective in cystic fibrosis (CF). The
conventional paradigm is that CFTR is activated through cAMP and protein kinase A (PKA) …