Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated
with the expression of TMEM16A, a Ca2+-activated Cl-channel. We asked whether …

Breathing is an intrinsic natural behavior and physiological process that maintains life. The
rhythmic exchange of gases regulates the delicate balance of chemical constituents within …

Background Cystic fibrosis (CF), caused by reduced CFTR function, includes severe
sinonasal disease which may predispose to lung disease. Newly developed CF pigs provide …

Background Saline‐based irrigation solutions are evidence‐based rhinological treatments;
however, the formulation of these solutions could theoretically alter the function of innate …

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR)
chloride channels causes defective secretion by submucosal glands (SMGs), leading to …

BACKGROUND: The submucosal gland (SMG) is important in the control of airway surface
fluid. Protease-activated receptor (PAR) 2 contributes to the pathophysiology of allergies in …

The ubiquitous bacterium Pseudomonas aeruginosa frequently causes hospital-acquired
infections. P. aeruginosa also infects the lungs of cystic fibrosis (CF) patients and secretes N …

Human and pig airway submucosal glands secrete mucus in response to substance P
(SubP), but in pig tracheal glands the response to SubP is> 10-fold greater than in humans …

The airway is kept sterile by an efficient innate defense mechanism. The cornerstone of
airway defense is mucus containing diverse antimicrobial factors that kill or inactivate …

Inhaled hypertonic saline (HTS) treatment is used to improve lung health in patients with
cystic fibrosis (CF). The current consensus is that the treatment generates an osmotic …