The ubiquitous bacterium Pseudomonas aeruginosa frequently causes hospital-acquired
infections. P. aeruginosa also infects the lungs of cystic fibrosis (CF) patients and secretes N …

Human and pig airway submucosal glands secrete mucus in response to substance P
(SubP), but in pig tracheal glands the response to SubP is> 10-fold greater than in humans …

Inhaled hypertonic saline (HTS) treatment is used to improve lung health in patients with
cystic fibrosis (CF). The current consensus is that the treatment generates an osmotic …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Protease-activated receptor 2 (PAR2), a G protein-coupled receptor expressed in airway
epithelia and smooth muscle, plays an important role in airway inflammation. In this study …

Mucus secretion from individual tracheal glands in adult ferrets was studied with time-lapse
optical imaging of mucus droplets under an oil layer. Density of functional glands …

Mucus clearance, a primary innate defense mechanism of airways, is defective in patients
with cystic fibrosis (CF) and CF animals. In previous work, the combination of a low dose of …

Airway submucosal gland serous cells are important sites of fluid secretion in conducting
airways. Serous cells also express the cystic fibrosis (CF) transmembrane conductance …

Эмфизема-одно из основных проявлений хронической обструктивной болезни легких
(ХОБЛ), а курение-один из наиболее значимых факторов риска. Результаты …

The airways are lined with a film of fluid 10 μm deep that acts as the first line of defense
against inhaled pathogens, dirt, and noxious vapors. Transepithelial fluid movements driven …