How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1−40

B Schwarze, D Huster - Macromolecular Bioscience, 2023 - Wiley Online Library
Amyloid fibrils represent the structural endpoint on the energetic (mis) folding landscape of
very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark …

Exploring the effect of inhibitor AKB‐9778 on VE‐PTP by molecular docking and molecular dynamics simulation

WS Liu, RR Wang, YZ Sun, WY Li, HL Li… - Journal of Cellular …, 2019 - Wiley Online Library
Diabetic macular edema, also known as diabetic eye disease, is mainly caused by the
overexpression of vascular endothelial protein tyrosine phosphatase (VE‐PTP) at …

Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations

RK Saini, S Shuaib, D Goyal, B Goyal - ACS omega, 2020 - ACS Publications
The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized
as a key player in the pathogenesis of Alzheimer's disease. Recent experiments reported …

Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics

RR Wang, Y Ma, S Du, WY Li, YZ Sun, H Zhou… - … Biology and Chemistry, 2019 - Elsevier
Juvenile myelomonocytic leukaemia, an aggressive myeloproliferative neoplasm, is
characterized by thrombocytopenia, splenomegaly, fever and excess myelomonocytic cells …

Effect of Piedmont mutation (L34V) on the structure, dynamics, and aggregation of Alzheimer's Aβ40 peptide

RK Saini, H Thakur, B Goyal - Journal of Molecular Graphics and Modelling, 2020 - Elsevier
The amyloid-β (Aβ) aggregation in the brain has been associated with the development of
Alzheimer's disease (AD). The previous studies have reported that Piedmont mutation …

[HTML][HTML] The F19W mutation reduces the binding affinity of the transmembrane Aβ 11–40 trimer to the membrane bilayer

TT Tran, F Pan, L Tran, C Roland, C Sagui - RSC advances, 2021 - pubs.rsc.org
Alzheimer's disease is linked to the aggregation of the amyloid-β protein (Aβ) of 40 or 42
amino acids. Lipid membranes are known to modulate the rate and mechanisms of the Aβ …

In vitro and in silico analysis of a E559K mutation on cartilage oligomeric matrix protein

J Qiu, J Tan - … Research/Fundamental and Molecular Mechanisms of …, 2022 - Elsevier
Pseudoachondroplasia (PSACH) is known as an autosomal dominant disorder associated
with mutations in the gene of cartilage oligomeric matrix protein (COMP). The …

[引用][C] How Single Site Mutations Can Help Understanding Structure Formation of Amyloid 𝜷

B Schwarze, D Huster - 2023