How Single Site Mutations Can Help Understanding Structure Formation of Amyloid β1−40
B Schwarze, D Huster - Macromolecular Bioscience, 2023 - Wiley Online Library
Amyloid fibrils represent the structural endpoint on the energetic (mis) folding landscape of
very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark …
very many proteins. Physiologically, amyloid fibrils are observed as a characteristic hallmark …
Exploring the effect of inhibitor AKB‐9778 on VE‐PTP by molecular docking and molecular dynamics simulation
WS Liu, RR Wang, YZ Sun, WY Li, HL Li… - Journal of Cellular …, 2019 - Wiley Online Library
Diabetic macular edema, also known as diabetic eye disease, is mainly caused by the
overexpression of vascular endothelial protein tyrosine phosphatase (VE‐PTP) at …
overexpression of vascular endothelial protein tyrosine phosphatase (VE‐PTP) at …
Impact of Mutations on the Conformational Transition from α-Helix to β-Sheet Structures in Arctic-Type Aβ40: Insights from Molecular Dynamics Simulations
The amyloid-β (Aβ) protein aggregation into toxic oligomers and fibrils has been recognized
as a key player in the pathogenesis of Alzheimer's disease. Recent experiments reported …
as a key player in the pathogenesis of Alzheimer's disease. Recent experiments reported …
Exploring the reason for increased activity of SHP2 caused by D61Y mutation through molecular dynamics
RR Wang, Y Ma, S Du, WY Li, YZ Sun, H Zhou… - … Biology and Chemistry, 2019 - Elsevier
Juvenile myelomonocytic leukaemia, an aggressive myeloproliferative neoplasm, is
characterized by thrombocytopenia, splenomegaly, fever and excess myelomonocytic cells …
characterized by thrombocytopenia, splenomegaly, fever and excess myelomonocytic cells …
Effect of Piedmont mutation (L34V) on the structure, dynamics, and aggregation of Alzheimer's Aβ40 peptide
RK Saini, H Thakur, B Goyal - Journal of Molecular Graphics and Modelling, 2020 - Elsevier
The amyloid-β (Aβ) aggregation in the brain has been associated with the development of
Alzheimer's disease (AD). The previous studies have reported that Piedmont mutation …
Alzheimer's disease (AD). The previous studies have reported that Piedmont mutation …
[HTML][HTML] The F19W mutation reduces the binding affinity of the transmembrane Aβ 11–40 trimer to the membrane bilayer
Alzheimer's disease is linked to the aggregation of the amyloid-β protein (Aβ) of 40 or 42
amino acids. Lipid membranes are known to modulate the rate and mechanisms of the Aβ …
amino acids. Lipid membranes are known to modulate the rate and mechanisms of the Aβ …
In vitro and in silico analysis of a E559K mutation on cartilage oligomeric matrix protein
J Qiu, J Tan - … Research/Fundamental and Molecular Mechanisms of …, 2022 - Elsevier
Pseudoachondroplasia (PSACH) is known as an autosomal dominant disorder associated
with mutations in the gene of cartilage oligomeric matrix protein (COMP). The …
with mutations in the gene of cartilage oligomeric matrix protein (COMP). The …