Experimental Evolution with Caenorhabditis Nematodes

H Teotónio, S Estes, PC Phillips, CF Baer - Genetics, 2017 - academic.oup.com
The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

[HTML][HTML] Flexible and disposable paper-and plastic-based gel micropads for nematode handling, imaging, and chemical testing

Z Njus, T Kong, U Kalwa, C Legner, M Weinstein… - APL …, 2017 - pubs.aip.org
Today, the area of point-of-care diagnostics is synonymous with paper microfluidics where
cheap, disposable, and on-the-spot detection toolkits are being developed for a variety of …

[HTML][HTML] Microfluidics for interrogating live intact tissues

LF Horowitz, AD Rodriguez, T Ray… - Microsystems & …, 2020 - nature.com
The intricate microarchitecture of tissues–the “tissue microenvironment”–is a strong
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …

Microfluidic devices for embryonic and larval zebrafish studies

A Khalili, P Rezai - Briefings in functional genomics, 2019 - academic.oup.com
Zebrafish or Danio rerio is an established model organism for studying the genetic, neuronal
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …

On-chip simultaneous rotation of large-scale cells by acoustically oscillating bubble array

Q Tang, F Liang, L Huang, P Zhao, W Wang - Biomedical Microdevices, 2020 - Springer
Bubbles locating in microfluidic chamber can produce acoustic streaming vortices by
applying travelling surface acoustic wave oscillation in an ultrasonic range, which can be …

Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

J Zhang, JH Hartman, C Chen, S Yang, Q Li, Z Tian… - Lab on a Chip, 2020 - pubs.rsc.org
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C.
elegans) based on different phenotypes is important for most worm research, especially …

[HTML][HTML] Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes

JC Puchalt, JF Gonzalez-Rojo, AP Gómez-Escribano… - Scientific reports, 2022 - nature.com
Data from manual healthspan assays of the nematode Caenorhabditis elegans (C. elegans)
can be complex to quantify. The first attempts to quantify motor performance were done …

[HTML][HTML] C. elegans electrotaxis behavior is modulated by heat shock response and unfolded protein response signaling pathways

SKB Taylor, MH Minhas, J Tong… - Scientific Reports, 2021 - nature.com
The nematode C. elegans is a leading model to investigate the mechanisms of stress-
induced behavioral changes coupled with biochemical mechanisms. Our group has …

Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices

K Youssef, A Tandon, P Rezai - Integrative Biology, 2019 - academic.oup.com
Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …