Experimental Evolution with Caenorhabditis Nematodes
The hermaphroditic nematode Caenorhabditis elegans has been one of the primary model
systems in biology since the 1970s, but only within the last two decades has this nematode …
systems in biology since the 1970s, but only within the last two decades has this nematode …
Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans
M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
[HTML][HTML] Flexible and disposable paper-and plastic-based gel micropads for nematode handling, imaging, and chemical testing
Today, the area of point-of-care diagnostics is synonymous with paper microfluidics where
cheap, disposable, and on-the-spot detection toolkits are being developed for a variety of …
cheap, disposable, and on-the-spot detection toolkits are being developed for a variety of …
[HTML][HTML] Microfluidics for interrogating live intact tissues
LF Horowitz, AD Rodriguez, T Ray… - Microsystems & …, 2020 - nature.com
The intricate microarchitecture of tissues–the “tissue microenvironment”–is a strong
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …
determinant of tissue function. Microfluidics offers an invaluable tool to precisely stimulate …
Microfluidic devices for embryonic and larval zebrafish studies
Zebrafish or Danio rerio is an established model organism for studying the genetic, neuronal
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …
and behavioral bases of diseases and for toxicology and drug screening. The embryonic …
On-chip simultaneous rotation of large-scale cells by acoustically oscillating bubble array
Q Tang, F Liang, L Huang, P Zhao, W Wang - Biomedical Microdevices, 2020 - Springer
Bubbles locating in microfluidic chamber can produce acoustic streaming vortices by
applying travelling surface acoustic wave oscillation in an ultrasonic range, which can be …
applying travelling surface acoustic wave oscillation in an ultrasonic range, which can be …
Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C.
elegans) based on different phenotypes is important for most worm research, especially …
elegans) based on different phenotypes is important for most worm research, especially …
[HTML][HTML] Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes
JC Puchalt, JF Gonzalez-Rojo, AP Gómez-Escribano… - Scientific reports, 2022 - nature.com
Data from manual healthspan assays of the nematode Caenorhabditis elegans (C. elegans)
can be complex to quantify. The first attempts to quantify motor performance were done …
can be complex to quantify. The first attempts to quantify motor performance were done …
[HTML][HTML] C. elegans electrotaxis behavior is modulated by heat shock response and unfolded protein response signaling pathways
SKB Taylor, MH Minhas, J Tong… - Scientific Reports, 2021 - nature.com
The nematode C. elegans is a leading model to investigate the mechanisms of stress-
induced behavioral changes coupled with biochemical mechanisms. Our group has …
induced behavioral changes coupled with biochemical mechanisms. Our group has …
Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices
Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …