Pharmacogenomics (PGx), examining the effect of genetic variation on interpatient variation
in drug disposition and response, has been widely studied for several decades. However, as …

Over the past two decades, Next-Generation Sequencing (NGS) has revolutionized the
approach to cancer research. Applications of NGS include the identification of tumor specific …

The inadequate efficacy and adverse effects of antipsychotics severely affect the recovery of
patients with schizophrenia spectrum disorders (SSD). We report the evidence for …

Pharmacogenetics, the study of how interindividual genetic differences affect drug response,
does not explain all observed heritable variance in drug response. Epigenetic mechanisms …

Background This pilot study aims to identify and functionally assess pharmacovariants in
whole exome sequencing data. While detection of known variants has benefited from …

Polygenic models have emerged as promising prediction tools for the prediction of complex
traits. Currently, the majority of polygenic models are developed in the context of predicting …

Lung cancer (LC) is one of the most common cancer-related mortality in the world. Even with
intensive multimodality therapies, lung cancer has a poor prognosis and a high morbidity …

© 2024 Sportiello and Capuano. This is an open-access article distributed under the terms
of the Creative Commons Attribution License (CC BY). The use, distribution and …

Antiplatelet therapy, the gold standard of care for patients with acute coronary syndrome
(ACS) undergoing percutaneous coronary intervention (PCI), is one of the therapeutic …

Pharmacogenomics (PGx) is an important component of precision medicine that promises
tailored treatment approaches based on an individual's genetic information. Exploring the …