BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the eighth most common
cancer with the lowest overall 5-y relative survival rate. Gene expression profiling of PDAC …

Progress in our understanding of heterotypic cellular interaction in the tumor
microenvironment, which is recognized to play major roles in cancer progression, has been …

Candidate risk genes for autism spectrum disorder (ASD) have been identified, but the
challenge of determining their contribution to pathogenesis remains. We previously …

In the last decade, the tyrosine kinase receptor cMET, together with its ligand hepatocyte
growth factor (HGF), has become a target in non-small cell lung cancer (NSCLC) …

The molecular mechanisms underlying the peritoneal dissemination of gastric cancer
remain unclear. Using in vivo metastatic models, this study attempted to clarify the role of …

Background Biomedical researchers often want to explore pathogenesis and pathways
regulated by abnormally expressed genes, such as those identified by microarray analyses …

Recent publications demonstrated that abnormal expression of Ezrin and c-Met proteins
were related to carcinogenesis, metastasis and prognosis of various sorts of tumors. In this …

A novel multicellular model composed of epithelial ovarian cancer and fibroblast cells was
developed as an in vitro platform to evaluate nanovector delivery and ultimately aid the …

Background c-MET is a receptor tyrosine kinase which is classically activated by HGF to
activate its downstream signaling cascades such as MAPK, PI3K/Akt/mTOR, and STAT3 …

Radiation therapy remains an imperative treatment modality for numerous malignancies.
Enduring significant technical achievements both on the levels of treatment planning and …