[HTML][HTML] Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

X Tong, R Tang, M Xiao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

[HTML][HTML] Role of pyroptosis in inflammation and cancer

X Wei, F Xie, X Zhou, Y Wu, H Yan, T Liu… - Cellular & molecular …, 2022 - nature.com
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

[HTML][HTML] Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

[HTML][HTML] Cuproptosis-related risk score predicts prognosis and characterizes the tumor microenvironment in hepatocellular carcinoma

Z Zhang, X Zeng, Y Wu, Y Liu, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Aims Cuproptosis is a recently identified form of programmed cell death; however, its role in
hepatocellular carcinoma (HCC) remains unclear. Methods A set of bioinformatic tools was …

[HTML][HTML] Pyroptosis: mechanisms and diseases

P Yu, X Zhang, N Liu, L Tang, C Peng… - Signal transduction and …, 2021 - nature.com
Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Photocatalytic superoxide radical generator that induces pyroptosis in cancer cells

L Yu, Y Xu, Z Pu, H Kang, M Li… - Journal of the …, 2022 - ACS Publications
Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing
attention as a promising approach to cancer immunotherapy. However, biocompatible …

[HTML][HTML] Gasdermin D in pyroptosis

BE Burdette, AN Esparza, H Zhu, S Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

[HTML][HTML] The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer

M Jiang, L Qi, L Li, Y Li - Cell death discovery, 2020 - nature.com
Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic
drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit …

[HTML][HTML] Diversity and complexity of cell death: a historical review

W Park, S Wei, BS Kim, B Kim, SJ Bae… - … & molecular medicine, 2023 - nature.com
Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

The concept of intrinsic versus extrinsic apoptosis

L Lossi - Biochemical Journal, 2022 - portlandpress.com
Regulated cell death is a vital and dynamic process in multicellular organisms that maintains
tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better …